Name | 4-Amino-2,6-dimethylpyrimidine |
Synonyms | KYANMETHIN Kyanmethin AKOS BC-0719 AKOS B029847 LABOTEST-BB LT00000110 2,6-dimethylpyrimidin-4-amine 4-AMINO-2,6-DIMETHYLPYRIMIDINE 4-Amino-2,6-dimethylpyrimidine 6-AMINO-2,4-DIMETHYLPYRIMIDINE 2,6-DIMETHYL-4-PYRIMIDINYLAMINE 2,6-dimethylpyrimidin-4-ylamine 4-Amino-2,6-dimethylpylpyrimidine |
CAS | 461-98-3 |
EINECS | 207-320-1 |
InChI | InChI=1/C6H9N3/c1-4-3-6(7)9-5(2)8-4/h3H,1-2H3,(H2,7,8,9) |
InChIKey | BJJDXAFKCKSLTE-UHFFFAOYSA-N |
Molecular Formula | C6H9N3 |
Molar Mass | 123.16 |
Density | 1.1097 (rough estimate) |
Melting Point | 184-186°C |
Boling Point | 254 °C |
Flash Point | 121.3°C |
Water Solubility | 6.4g/L(18 ºC) |
Solubility | DMSO |
Vapor Presure | 0.0417mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
Merck | 14,5326 |
pKa | 7.24±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.5589 (estimate) |
MDL | MFCD00006106 |
Physical and Chemical Properties | Yellow needle-like crystals. Melting point 191-192 C (183 C), sublimation, 18 C, 1G can be dissolved in 0.64mg water and 5.25g ethanol. There is an odor of ammonia. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
HS Code | 29335990 |
use | pharmaceutical intermediates. It is used to produce sulfadimethylisopyrimidine. During production, it is condensed with acetaminobenzenesulfonyl chloride (ASC) to obtain 6-acetaminobenzenesulfonamido-2, 4-dimethylpyrimidine, and then hydrolyzed to obtain sulfadimethylisopyrimidine. |
production method | acetonitrile reacts with sodium ammonia: acetonitrile is added to a dry high-pressure tank, then sodium ammonia is rapidly added, and the reaction is carried out at 135-150 ℃ for 1.5h at a pressure of about 0.8-1MPa to obtain crude cyclists by cooling. Dissolve the crude product with hot water. Filtration, the filtrate is concentrated into a refined product. |